According to the complex mining geological condition of Shandong gentle inclined multi-seam mining, Use the three-dimensional finite element numerical analysis software to establish three-dimensional geological model under the different mining working conditions. Taking into account the impact of faults to calculate multi-seam roof strata movement and surface subsidence caused by the different mining working conditions. The level displacement & subsidence distribution curve of the reference point of surface & multi-seam roof strata under the different working conditions is shown. The maximum, minimum settlement, differential settlement and subsidence diagram is shown. And the principal stress, shear stress value of surface & multi-seam roof strata after mining also is shown. The results showed that: little change of the biggest surface subsidence and differential settlement is caused by mining 3101&3102 face or separate 3101 or 3102 face. And the largest subsidence, and the settlement difference of the surface is 520mm, 498mm, 515mm and 59mm, 78mm, 81mm, Respectively. It provides an reference for reasonable, safe, economic for the inclined multi-seam mining under similar conditions.