Based on the theory study of stress characteristics of the H-beam with corrugated web under transverse load, optimization analysis was conducted. The optimization analysis focused on the corrugation configuration of web, by which one optimized dimension was put forward. To verify the optimization result, total 10 specimens are tested. From the results, the optimization configuration can provide relatively high shear strength and ductility property, with low steel usage. So it can be put into production practice.