In order to promote the applications of steel and concrete composite girder with concrete-filled tubular up-flange (SCCGCFTF) in practical bridge engineering, some actual issues for SCCGCFTF bridge structures have been discussed. The finite element static and dynamic analysis models of SCCGCFTF and conventional composite I-shape girder (CCIG) bridge structures were established. Then the stiffness, stress and dynamic characteristics of these composite girder bridges were studied and compared. Based on the numerical analysis results, the mechanical characters of SCCGCFTF bridges are obtained, and some design rules for SCCGCFTF bridges are also proposed. The analysis results show that SCCGCFTF bridges have high practical engineering application value.