Based on the characteristic of cooler frame, the finite element model of air cooler frame is established using ANSYS software. Equivalent static load method and response spectrum method were used for the seismic performance analysis of cooler frame. The equivalent static load is applied at the center of gravity of various masses using MPC184 rigid beam for transferring the load. The deformation and stress of cooler using equivalent static load method are larger than that of cooler using spectrum response method. For this reason, it can be said that the equivalent static load method is more conservative. At last the deformations and stresses of cooler frame using two methods are checked by ASME AG-1 specification. The results showed that the deformation and stress of cooler frame meet the requirements.