Using high pure magnesia and magnesia-spinel as the main raw material, keeping the same quantity of spinel, specimens were made with different spinel size distribution (≤0.044mm, 1-0mm, 2-1mm, 3-2mm and 3-1mm). Dextrin and brine are the binder. Specimens were dried at the temperature of 110°C for 24 hours, sintered at the temperature of 1680°C holding 8 hours in a tunnel kiln. The properties and microstructure of the specimens were analyzed. The results are shown that the addition of spinel with grain size of 3-1mm improves sintering of magnesia-spinel brick, with the thermal shock resistance reaching 18 cycles, the cold crushing strength reaching 54 MPa, improving the comprehensive performance of the magnesia-spinel brick.