To protect circumstance and improve of structure durability of Cao’e River floodgate, high volume industrial residue concrete (HVIRC) was prepared, and its mechanical property and durability were studied systematically. 10% of fly ash and 40% of ground granulated blast-furnace slag was used to replace 50% of cement in HVIRC. HVIRC had better anti-carking ability with larger tensile strength, larger ultimate tensile strain, larger tensile-compressive strength ratio and smaller elastic modulus-to-strength ratio. Dry shrinkage rate of HVIRC was similar with that of ordinary Portland concrete (OPC). HVIRC had higher compactness with smaller gas diffusion coefficient and relative permeability coefficient. Expansion caused by alkali-silica reaction reduced greatly by using high volume industrial residue and alkali-silica reaction was controlled markedly. HVIRC had better property of chloride ion penetration resistance with low effective diffusion coefficient. HVIRC could protect steel-bar from premature corrosions. Properties of sulfate resistance and frost resistance of HVIRC were also favorable. It’s proved that high volume industrial residue can enhance greatly mechanical property and durability of concrete and HVIRC can be used in Cao’e River floodgate.