Culture-led urban regeneration is an influential planning strategy in Western countries, which is to maintain the city character while enhancing the overall competitiveness of the city through the construction of cultural development to meet the urban environment of the new cultural needs. For the moment, the rapid development of social economy of Chongqing has accelerated its urbanization process. As one of the available land stock resources of urban, existing-blocks need updating to meet the new environmental requirements immediately because of physical and functional decline. So it is essential to consider the strategy of culture-led urban regeneration synthetically. It can not only maintain the social network structure and neighborhood relationship of the existing-blocks to continue urban context while improving its image, but also provide a sustainable competitive city. Taking existing-blocks in Chongqing as the main research object, analyze the current characteristics of the existing-blocks, then put forward the culture-led planning strategy from macro, micro and mid-scale to adapt the development of Chongqing existing-blocks by drawing on the experience at home and abroad.