Statical analysis of infilled frame structure was conducted on 3D finite element models by means of software ANSYS10.0. Analyses on relevant parameters of infilled frame walls with or without openings have been carried out seperately, and it is found that the relevant stiffness of the model gradually increases with the ratio of the wall’s width to its height. However, the effection of the width to height ratio of the wall on its structural lateral stiffness becomes much smaller when the value of the width to height ratio is larger than 1.5. The effection can be basically ignored when the width to height ratio is larger than 1.8. It is investigated that the ratio of posts inertia moment to beams has great influence on model’s relevant stiffness. The relevant stiffness of frame structure decreases with the growth of the ratio of posts inertia moment to beams (I2/I1). For a long time, Filling Wall is widely used in multi-storey buildings and Civil Construction Structures, for its flexible architecture flats and large interior space, etc. However, because of the imperfection in analysis methods and the defects in model, pure- framework design is used in civil architectures, and the weight of filling wall is calculated by converting to the Line Load on the beam. According to the analysis of 5.12 Wenchuan earthquake, the early filling wall absorbs a large earthquake because of its stiffness, while its Adhesive Tensile Strength is low, which making the earthquake-damage to the filling wall is more serious than that to the frame structure. By analyzing the parameters in non-opening and opening filling wall and changing a given parameter, while keeping other parameters unchanged. This paper studies the influence on the Lateral Stiffness of Frame Structure, to provide Earthquake Fortifying Areas with reference data in the design process of filling wall.