With a special structure system and architectural shape, Kelamayi Exhibition Building has a quite complicated seismic response and dynamic behavior. Based on performance-based seismic design method, vibration characteristics and seismic response under different earthquakes are researched in this paper. Elastic-plastic model is made, and elastic-plastic time history analysis of structure subjected to strong earthquake is carried out, to verify the bearing capacity of the structure according to aseismic behavior indexes. The results of static analysis and elastic-plastic time history analysis show that, the maximum storey drift angle is less than the limit value 1/100. Parts of the structure is in plastic, but not deep, and can be put into use after some repairment. In a word, Kelamayi Exhibition Building can meet the requirement of seismic fortification and fixed aseismic behavior indexed, and have enough seismic bearing capacity.