This paper presents experimental and numerical simulation for deformation and fatigue life prediction of various cables, such as electrical, optical and network cables. The cable damage is produced by the tensile, bending and torsional action under moving and fixing condition, and by direct external impact. To obtain material responses of the cable, uniaxial tensile tests and drop-weight impact tests were adopted, and the nonlinear constitutive equations based on various strain energy potentials or material models were employed to analyze deformation of polymer sheath and metallic armor layer of the cable. Finite element results were compared with experimental data for deformation and impact absorption energy of the cable during direct external impact. Also, fatigue strength of the cable was predicted from variation of calculated stress level under tensile conditions. Fractured surface of the cable were analyzed by scanning electron microscopy (SEM).