The effect of Ca and Sr content on the microstructure and mechanical properties of a cast AZ91 magnesium alloy is investigated. Ca and Sr additions in AZ91 magnesium alloy are expected high creep resistance. The microstructure of the alloy exhibits the dendritic α-matrix and the second-phases forming networks on the grain boundary. Tensile tests at elevated temperatures between 448 and 523K reveal that the creep resistance was improved with increasing the additional amount of Ca, especially more than 1.0wt%. From the perspective of grain refinement effect, it is expected that the additions of Ca and Sr to AZ91 magnesium alloy not only improve creep resistance but also improve mechanical properties at room temperature.