Paper Title:
Evaluation of BAp Orientation Using Mouse Models for Osteoporosis (OPG-KO) and Osteopetrosis (op/op)
  Abstract

Bone microstructure and its functions are maintained by the activity of bone cells such as osteoclast for bone resorption and osteoblast for bone formation. In this study, we examined the role of osteoclast on the formation of the preferential orientation of biological apatite (BAp) as a bone quality parameter using OPG-KO and op/op mouse models in which the expression of osteoclast increases for osteoporosis and decreases for osteopetrosis. The orientation degree of the BAp c-axis was analyzed by a microbeam X-ray diffraction system. We found more decrease in the preferential alignment of the BAp c-axis along the longitudinal direction of bone in the femoral bones of both OPG-KO and op/op mice at 12 weeks compared with normal control mice. We concluded that changes in the amount and activity of osteoclast affect BAp alignment, resulting in the degradation of bone microstructure in osteoporosis and osteopetrosis.

  Info
Periodical
Advanced Materials Research (Volumes 26-28)
Edited by
Young Won Chang, Nack J. Kim and Chong Soo Lee
Pages
761-764
DOI
10.4028/www.scientific.net/AMR.26-28.761
Citation
J. W. Lee, T. Nakano, S. Toyosawa, Y. Tabata, Y. Umakoshi, "Evaluation of BAp Orientation Using Mouse Models for Osteoporosis (OPG-KO) and Osteopetrosis (op/op)", Advanced Materials Research, Vols. 26-28, pp. 761-764, 2007
Online since
October 2007
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