The grinding precision of end-mill is dependent on the surface roughness of the corresponding rake face and relief face. This precision will be influential in the surface roughness of workpiece and tool life of end-mill in high-speed milling. Firstly, the experiment of high-speed milling for SKD61 tool steel has been performed in the different cutting condition, and the end-mills have the different surface roughness. From the experimental results, it has shown that small relief surface roughness will decrease tool flank wear (increase tool life). The surface integrity of end-mill is very important for high-speed milling, so the different grinding parameters of end-mill have been utilized in the grinding experiment. Finally the surface roughness analysis model of the end-mill relief could be established by a polynomial network. The predictive model of surface roughness can be used to analyze the grinding precision of end-mill.