In recent years, it has been proposed that the new era of implants design should be focused on the use of the new generation of biocompatible materials or reengineers the currently available materials. The objective of this research was to study cell-metal interactions using highly porous TiO2 foam. To obtain the porous TiO2 foam, polymeric foam replication methods might be one of the most effective methods. Surface chemical composition, morphology and phase are investigated by field emission scanning electron microscope (FESEM) and X-Ray Diffraction (XRD). In vitro cellular response of cells has been studied on TiO2 foam. In the investigations of the cellular responses of cells, two aspects were considered: the number of growing cells and their morphological features. It was clear that rough surface morphology was important factor for better cell-metal interaction. Surface topography can affect the cell migratory significantly and adhesion behavior on implant surfaces.