The paper is concerned with topology optimization in the mechanical design process. The disadvantage of current process of mechanical design is discussed and a new design process based on structural topology optimization is presented. The design process with structural topology optimization in mechanical design is discussed by the example of the frame of a bender. Static analysis is made to the original model first according to the whole structure and working characteristic of the machine, the stress and deformation distribution are obtained and then topology optimization is carried out. On the basis of topology optimization, the layout of the initial design proposal is obtained and the weight of the frame is substantially reduced while the performance enhanced. The application of the method demonstrates that through innovative utilization of the topology optimization techniques, the conceptual proposals can be obtained and the overall mechanical design process can be improved substantially in a cost effective manner.