Directing at the characteristics of the basic chemistry, the paper discusses the characteristics of the “Inorganic chemistry”, “organic chemistry”, “physical chemistry” and “analytical chemistry”, and points out that application of multimedia in the basic chemistry is in line with student’s learning and cognitive rules. And multimedia teaching can greatly improve the teaching efficiency, extend the class size and optimize the teaching effect, which is an important way to teaching reform of course in the Information Age. Then it analyzes the unique role played in teaching by media. While, if multimedia technology is not rationally used in this field, the results will be counterproductive. We try to display the advantages of multi-media teaching and strive to overcome its fault in the teaching process. We also do some discussion on the effects of improving the teaching continuously.