This presentation proposed an autocorrelation-based signal detection scheme to get a better resulting. The signal detection scheme is combined by Autocorrelation Filter and an improved linear Minimum Mean Square Error (MMSE) estimator. The Autocorrelation Filter is used to reject the interference, and the improved linear MMSE estimator is used to get the least error. Both two methods are based on the non-overlapping property of the signals in autocorrelation domain. The theory consequence and Simulation results indicate that this signal detection scheme can achieve a high detection quality.