Heavy-duty aerospace components are frequently hot forged to satisfy the high requirements concerning their mechanical behaviour. Only the usage of high-performance materials together with a near-optimum manufacturing process enables the production of parts that are at the same time lightweight and mechanically extremely durable. Not only the static properties, but also the fatigue behaviour of Inconel718 is strongly influenced by the material’s microstructure resulting from the forging and heat treatment processes. Therefore, the static and fatigue properties may be controlled via the microstructural properties by suitably adjusting the parameters of the manufacturing processes. The present work links the complete forging and heat treatment process to the local distribution of the material’s fatigue strength within a component; the effect of the operating temperature is also considered. To this purpose, an empirical model is derived from fatigue tests on specimens with different microstructures at different temperatures. The resulting fatigue strength model is implemented, along with a microstructural evolution model from earlier work , into a finite element code in order to predict the local fatigue strength distribution in a component after being subjected to an arbitrary forging process. In a further step, the finite element code is linked to an optimization tool for determining the optimum set of manufacturing process parameters such that the component lifetime is maximized while taking process constraints into consideration.