Aerospace gas turbine disks operate in an environment of relatively high stresses caused by centrifugal forces and elevated temperatures. Because of the strong mechanical requirements and narrow specifications of such parts not only a correct, defect free final geometry is necessary, but also a defined microstructure. Even though the microstructure evolution during thermo-mechanical processing is well studied and understood for superalloys like IN718, the influences cannot easily be described analytically. Thus simulation tools are used to assure process stability and to optimize design parameters to meet the tough requirements in aerospace industries. Microstructure simulation of IN718 (and other materials) is well established at Bohler Schmiedetechnik GmbH & Co KG and appreciated by its customers. The advent of the newly developed nickel-base superalloy ATI Allvac® 718PlusTM led to extensive investigations and the development of an adapted microstructure model by Bohler Schmiedetechnik GmbH & Co KG and its research partners. Aim of this paper is a comparison of the microstructure evolution in IN718 and ATI Allvac® 718PlusTM during the thermo-mechanical treatment of turbine disks. Influences of process temperature, strain and strain rate on the final grain size are discussed by finite element simulations with a coupled grain structure model. Experimental results from trial forgings are compared with the outcome of the microstructure simulations.