The setting goals of process lubrication were not all-inclusive in the previous manufacturer of double cold reduction. Strip shape, surface quality, the fuel consumption of unit and rolling stability could not be considered comprehensively. Aimed at the equipment and production craft characters of double cold reduction unit, at the basis of putting forward the comprehensive control index of a strip-shaped fuel consumption cleanliness for the first time, ensuring the shape quality of strip, lowering the oil residue on strip surface, improving the cleanliness of strip surface and reducing fuel consumption were defined as control targets; besides, the control of slip and heat-scratches were defined as constraints. A complete comprehensive optimization technology of process lubrication regime was established and has been applied to a 1220 double cold reduction unit belonging to Baosteel in China. Rolling speed, surface quality and strip shape quality are improved effectively, and oil consumption is reduced, meanwhile, the productivity and rolling yield of unit are ensured. This technology has created economic benefits for domestic steel makers and has further extended application value.