Portland cement can be used as soil stabilizer, but poses some problems such as dust pollution, consumption of fossil energy and relatively large amounts of calcium-rich raw materials. Enzyme as a soil enzymatic stabilizer is a natural organic compound and promising material to reduce the application of Portland cement. Perma-Zyme is one type of enzyme. The results of the study showed that soil type and curing method significantly affected the effectiveness of the treatments with Perma-Zyme and Composite Portland cement. Under the air-dry conditions, the unconfined compressive strengths of soils stabilized with Composite Portland cement were lower than those treated with Perma-Zyme at each age. In sealed glass containers, the unconfined compressive strengths of soils treated with Composite Portland cement were higher than those treated with Perma-Zyme. These results indicate that after compaction, the surface of soil stabilized with Portland cement should be moistened with a spray of some water or cover with materials (such as plastic sheet)，but the surface of soil stabilized with Perma-Zyme need not spray water and cover with materials in the actual project construction.