Paper Title:
Synthesis, Antioxidant and Anticancer Activities of Efficient Glutathione Peroxidase Mimic
  Abstract

Glutathione peroxidase (GPX) is a well-known selenoenzyme that can protect cells against oxidative damage. A novel dicyclodextrinyl ditelluride (2-TeCD) compound was devised as a functional mimic of the GPX. The antioxidant effect of 2-TeCD was evaluated by its ability to protect mitochondria from oxidative damage. 2-TeCD could also suppress the TNF-α induced inflammatory effect on HUVECs surface in a dose-dependent manner. Meanwhile, 2-TeCD exhibited anti-proliferative property both in vitro and in vivo. These results indicate that 2-TeCD may be useful for developing medical agents in many pathological conditions such as cataract­, age-related diseases­, atherosclerosis, cancer and so on.

  Info
Periodical
Advanced Materials Research (Volumes 282-283)
Chapter
Chapter2: Material Science, Environment Science and Engineering
Edited by
Helen Zhang and David Jin
Pages
317-321
DOI
10.4028/www.scientific.net/AMR.282-283.317
Citation
T. T. Lin, J. Q. Liu, "Synthesis, Antioxidant and Anticancer Activities of Efficient Glutathione Peroxidase Mimic", Advanced Materials Research, Vols. 282-283, pp. 317-321, 2011
Online since
July 2011
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Young Soo Han, Yun Hwa Kim, Yeon Sook Yun, Soo Jin Jeon, Ki Sung Kim, Sung Hee Hong, Chang Soe Park, Jie Young Song
Abstract:Ceramides are well-known second messengers which mediate apoptosis, proliferation, differentiation in mammalian cells, but the physiological...
536
Authors: V. Kojić, D. Jakimov, G. Bogdanović, A. Djordjević
Abstract:The aims of this paper were to investigate cell growth activity of fullerenol C60(OH)24, its modulating effect on antitumor drug-induced...
543
Authors: De Wen Li, Xiao Xue Wei, Jing Hua Yu, Yuan Gang Zu
Environmental Biotechnology
Abstract:Taxus chinensis var. mairei was used as test material, exogenous nitric oxide (NO) fumigation treatment with different concentration (0,...
427
Authors: Qiu Sheng Lin, Hai Ning Yu, Undurti N Das, Sheng Rong Shen
Chapter 10: Chemical Biology and Medicinal Chemistry
Abstract:Natural antioxidants could inhibit ROS production and attenuate injury, which is important event of cardiovascular diseases. Water caltrop...
1757
Authors: Tian Rong Guo
Chapter 1: Environmental Chemistry, Biology and Technology
Abstract:Photosynthetic pigment content and photosynthetic activity, as well as the antioxidant capacity were estimated in barley seedlings after 10...
467