Paper Title:
The Anti-Inflammatory Effects of Biomaterials Cross-Linked with Genipin
  Abstract

This study was aimed to investigate the anti-inflammatory effects of the chitosan/gelatin membrane cross-linked with genipin (GP). Fourier transform infrared spectrophotometry (FT-IR) was used to characterize the cross-linking reaction. The XTT assay was applied to evaluate the cytotoxicity of the chitosan/gelatin membrane with RAW264.7 cells. Production of nitric oxide (NO) was measured by the Griess colorimetric method. The gene expression levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and IL-6 were detected by quantitative real-time reverse-transcription polymerase chain reaction (real-time RT-PCR). These results suggested that the anti-inflammatory effects of genipin cross-linked chitosan/gelatin membrane might be the results from modulating the NO/iNOS pathway and inhibiting the mRNA expression of COX-2, IL-6 in activated macrophages.

  Info
Periodical
Advanced Materials Research (Volumes 282-283)
Chapter
Chapter 3: Material Science, Chemistry and Information Technology
Edited by
Helen Zhang and David Jin
Pages
412-416
DOI
10.4028/www.scientific.net/AMR.282-283.412
Citation
Y. F. Song, S. S. Ding, Y. L. Cui, Q. S. Wang, L. Ye, Y. Zhang, "The Anti-Inflammatory Effects of Biomaterials Cross-Linked with Genipin", Advanced Materials Research, Vols. 282-283, pp. 412-416, 2011
Online since
July 2011
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Price
$32.00
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