This paper presents the study of the influences of cooling holes on the creep life behavior in the modeling specimen of single crystal cooling turbine blade at high temperature. Thin-walled cylindrical specimens with holes are tested to model the air-cooled turbine blade. Specimens without holes are also studied to make comparisons. Experimental results show that at 900°C, the creep lives of specimens with holes are longer than those of specimens without holes. Scanning Electron Microscopy (SEM) analyses reveal that creep deformations occur firstly around the cooling holes and finally rupture at the region with low stress and strain. Finite element analyses are used to study the creep damage development by a K-R damage model which has been implemented into the Abaqus user subroutine (UMAT). Simulation results show that stress concentration and redistribution occur around the cooling holes during the creep development. It is also shown that the maximum strain and stress are around the cooling holes which are the initial rupture region in the experiments.