The copolymerization reaction between glucose and acrylamide was initiated using Ce(NH4)2(NO3)6 as initiator under microwaves heating at 60~80°C. The product is glucose-acrylamide copolymer. The synthesis experiment shows that the copolymerization was initiated quickly when the dosage of glucose is 2~30%. When the optimal dosage of glucose is 20%, the average rate of acrylamide and glucose is 10∶1 in the long chain of the copolymer molecule; the average molecular weight of the copolymer is 3.61×108. The flocculating test showed the water-solubility of the copolymer is better than polyacrylamide, and with the same flocculating effect. The copolymer will easy to be biodegraded because that with amount of the glucose in its long chain molecules.