This research applied molecular dynamics method to micro Couette flow of nanofluids, in order to examine the absorption layer near solid surfaces, and propose mechanisms of heat transfer enhancement due to flow. The model of nanofluids consisted of 4 nm Cu nanoparticles and liquid argon as base liquid, Lennard-Jones potential function was adopted to deal with the interactions between atoms. Through visual observation and analysis, it was found that the even-distributed liquid argon atoms near solid surfaces could be seemed as a reform to base liquid and had contributed to heat transfer enhancement. In the process of Couette flow, nanoparticles were rotating and vibrating besides moving translationally. The micro-motions of nanoparticles could disturb the continuity of fluid and strengthen partial flow nearby nanoparticles, and enhance heat transfer in nanofluids.