Paper Title:
Characteration of Protein Loaded Chitosan Nanoparticles at Different pH Values
  Abstract

In this paper, the properties of chitosan (CS) nanoparticles (CS NPs) and Bovine Serum Albumin (BSA) loaded chitosan nanoparticles (BSA-loaded CS NPs) prepared with sodium tripolyphosphate (TPP) at different pH values were discussed. In addition, BSA encapsulation efficiency, zeta potentials and size of CS NPs and BSA-loaded CS NPs were characterized. The results indicated that sizes of CS NPs presented “V” change along with increase of pH values, while the size of BSA-loaded CS NPs showed “U” shape change. BSA encapsulation efficiency reached the biggest value when the pH value was 5.5. Zeta potentials of CS NPs and BSA-loaded CS NPs kept going down when the pH values were increasing, and positive potential of CS-loaded BSA CS NPs became higher than that of CS NPS when the pH value was more than 5.5. BSA-loaded CS NPs prepared at pH 5.5 exhibited regular and close to spherical in shape under transmission electron microscopy (TEM) sight.

  Info
Periodical
Advanced Materials Research (Volumes 284-286)
Chapter
Micro/Nano Materials
Edited by
Xiaoming Sang, Pengcheng Wang, Liqun Ai, Yungang Li and Jinglong Bu
Pages
950-953
DOI
10.4028/www.scientific.net/AMR.284-286.950
Citation
Y. Liu, Y. Sun, Y. L. Li, S. C. Xu, Y. X. Xu, "Characteration of Protein Loaded Chitosan Nanoparticles at Different pH Values", Advanced Materials Research, Vols. 284-286, pp. 950-953, 2011
Online since
July 2011
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Price
$32.00
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