Paper Title:
Synthesis and Characterization of 5-Fluorouracil and Polyethylene Glycol Esters as Prodrugs
  Abstract

A series of novel polyethylene glycol derivates was synthesized by esterification of chloroacetic acid with polyethylene glycol.The PEG-5-FU conjugates were characterized by FT-IR, 1H-NMR and UV spectroscopy. The result showed that 5-FU was successfully connected to the ends of PEG ester. Drug content of PEG2000-5-FU conjugate achieved 17.4%. As the molecular weight of PEG increased, the water solubility of prodrugs improved. When the molecular weight of PEG reached 2000, the conjugate had the best water solubility and the highest drug release rate.

  Info
Periodical
Advanced Materials Research (Volumes 287-290)
Chapter
New Energy Materials
Edited by
Jinglong Bu, Pengcheng Wang, Liqun Ai, Xiaoming Sang, Yungang Li
Pages
1509-1512
DOI
10.4028/www.scientific.net/AMR.287-290.1509
Citation
C. W. Li, G. Li, J. C. Zuo, "Synthesis and Characterization of 5-Fluorouracil and Polyethylene Glycol Esters as Prodrugs", Advanced Materials Research, Vols. 287-290, pp. 1509-1512, 2011
Online since
July 2011
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Price
$32.00
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