A series of V-Cr/SBA-15/Al2O3/FeCrAl metal monolithic catalysts with V content of 10wt% and Cr contents from 0 to 12.5wt% were prepared. The structure of the catalysts was characterized using XRD, XPS and TPR techniques. The catalytic activity for oxidative dehydrogenation (ODH) of propane with CO2 was evaluated. The results indicate that the mesoporous structure of SBA-15 was retained after vanadium and chromium incorporation and the vanadium species were well dispersed. The V-Cr/SBA-15/Al2O3/FeCrAl catalyst with 10wt% V and 10 wt% Cr exhibited the best activity with a propane conversion of 49.9% and a propylene selectivity of 86.5% at 650 °C.