Paper Title:
In Vitro Degradation and Biocompatibility of WE43, ZK60, and AZ91 Biodegradable Magnesium Alloys
  Abstract

Successful application of magnesium alloys as degradable load-bearing implants is determined by their biological performance especially degradation and corrosion behavior in the human body. Three magnesium alloys, namely WE43, ZK60, and AZ91 are investigated in this work. The in vitro degradation behavior, cytotoxicity, and genotoxicity are evaluated by corrosion tests, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and micronuclei tests, respectively. Immersion tests indicate that the ZK60 alloy has the best corrosion resistance and lowest corrosion rate in Hank’s solution, followed by AZ91 alloy and WE43 alloy in that order. The MTT results obtained from the three magnesium alloys after 7 days of immersion indicate good cellular viability. However, excessively high aluminum and magnesium concentrations have a negative influence on the genetic stability.

  Info
Periodical
Advanced Materials Research (Volumes 287-290)
Chapter
Biomaterials
Edited by
Jinglong Bu, Pengcheng Wang, Liqun Ai, Xiaoming Sang, Yungang Li
Pages
2008-2014
DOI
10.4028/www.scientific.net/AMR.287-290.2008
Citation
C. L. Liu, J. Jiang, M. Wang, Y. J. Wang, P. K. Chu, W. J. Huang, "In Vitro Degradation and Biocompatibility of WE43, ZK60, and AZ91 Biodegradable Magnesium Alloys", Advanced Materials Research, Vols. 287-290, pp. 2008-2014, 2011
Online since
July 2011
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