Ducted propeller is a normal thrust used widely in ship field, and the traditional design method could be improved by advanced computer technology of integrated design. Surface panel method predicting hydrodynamic performance of propeller and CFD were both used here, to ensure the results from surface panel method were believable. Surface panel program of ducted propeller was integrated in iSIGHT optimization platform, where the pitches in different radius were optimized and studied to find the best scheme. Design of experiment was selected as optimal method. Design variables were auto-chosen in the design space and optimal process was auto-executed. Besides, the effect of parameters to objective was gained. The final result showed that this method which can improve the efficiency of ducted propeller and realize the motivation provided a new idea for propeller design.