In order to study the effect of tire operating mode on its safety performance, a high-speed tire test-bed was put forward. The dynamic characteristic of drum was important for test result. To avoid the resonance of loaded drum during operation, the topological optimization analysis of drum with I-shaped structure was fulfilled with the element density as variables and the volume reduction of fifty percent as constraint condition and the first natural frequency as objective function. The optimal density distribution of drum was obtained within the constraint of the first natural frequency. Based on the analysis result of topology optimization, the drum structure with I–shaped was modified. The structure size of the new and improved drum was optimized with 50 iterative calculations using ANSYS. On the condition that the first natural frequency of drum was over 60Hz, the structure size of drum was optimal when the rate of the first natural frequency and total weight was highest and equaled to 0.05391. The optimization results showed the first natural frequency of drum was raised by 21.972Hz and its total weight was reduced by 69.95Kg.