In this paper, with the ANSYS, stress distribution and safety factor of connecting rod were analyzed by using 3D finite element method. The results show that the oil-hole of small end and medial surface of connecting rod shank are the exposed destructive positions at maximum compression condition. Maximum stress value is 214 MPa. Safety factor is 1.64. The oil-hole of small end and the transition location of small end are the exposed destructive positions at maximum stretch condition. Maximum stress value is 97.2MPa. Safety factor is 3.63. Based on the analysis, the structure of connecting rod is improved. Safety factor of connecting rod increase.