In order to realize the environmental hazard, this paper presents the investigation of the machinability of ball-end milling process with the dry cutting, the wet cutting, and the mist cutting for aluminum. The relations of the surface roughness, the cutting force, and the cutting parameters are examined based on the experimental results by using the Response Surface Analysis with the Box-Behnken design. The in-process cutting force is monitored to analyze the relations of the surface roughness and the cutting parameters. The proper cutting condition can be determined easily referring to the minimum use of cutting fluid, and the minimum surface roughness and cutting force of the surface plot. The effectiveness of the obtained surface roughness and cutting force models have been proved by utilizing the analysis of variance at 95% confident level.