This paper focuses on evaluation of the heat exchange process based on cumulative exergy analysis method. The case study chosen is the countercurrent heat exchange process that is widely used in the industrial processes. The optimal design is achieved by minimizing the annual total cumulative exergy consumption of the cold stream. The natural resource-oriented mathematical models are established in details. Obviously, the results from cumulative exergy optimization are imposed by the present state of the technology compared with the ones from thermoeconomics.