The influence of hydrogenation on structure and properties of TC4 alloy by die forming and sintering using hydrogenated powder was researched and the modification mechanism was analyzed by means of the room-temperature die forming and sintering in protection air to produce titanium alloy. The results show that, with the increase of hydrogen content and sintering temperature, the structure of TC4 titanium production using hydrogenated powder by die forming and sintering was changed from Widmanstaten structure to duplex structure. The density of TC4 titanium production shows a rise trend gradually. After annealing, the structure of TC4 titanium production gets more uniformity and refinement obviously, the compress yield limit shows a rising trend gradually, and the hydrogen content of TC4 alloy safety state is achieved. The density and mechanical property of TC4 titanium alloy with hydrogen content of 0.42wt % is the best.