The hot deformation behavior of the Zn-8Cu-0.3Ti alloy was researched by compression test on Gleeble-3500 thermo-simulation machine. The results indicated that the flow stress increased rapidly with the increase of the strain at the initial stage, however, the flow stress decreased and become steady when the strain exceed a certain value. The steady stress and peak stress increased with the decrease of the deformation temperature and the increase of the strain rate. The variation regulation of the deformation activation energy and stress exponent with the strain was established through the regression method. The hot deformation constitutive relationship was also established. Comparing with the experimental results, it was proved that the model reflected the real deformation feature of Zn-8Cu-0.3Ti zinc alloy.