Comparing with the traditional welding technology, laser welding of the diamond core drill bit has much merit that easy to realize automatic control and the production efficiency is high. It is the important direction of originality innovation on the diamond tool. Aim at the characteristics that more specification, higher accuracy and bad welding of diamond core drill bit, the laser welding technology was designed by “uniform design”. The technological parameter of experiment was presented by uniform design software and abundant experience. The experiments show that the welding seam is smooth and the flexural strength is 2000 N/mm2 which is higher as the European Designing Standard for the same product, and it is better than others in reliability safety and stabilization, when the welding speed is 1600 mm/min and the welding power is 1700 W. The study has significance of guiding and reference to the industrial production of diamond core drill bit.