The simulation analysis and research on crank linkage mechanism, which is the core part of the engine, are of important significance. Based on related theory, this paper introduces a simulation analysis method for crank linkage mechanism, which is using Pro/E. First of all, the 3D model of the mechanism is build; all the components are modeled and assembled. Then dynamic simulation for the crank linkage mechanism by using PRO/Mechanism is carried on, the result of characteristics of motion, stress, etc of the mechanism are shown. A more effective method about the simulation analysis of crank linkage mechanism is introduced in this paper.