In this paper, research was focused on the synthesis of a new efficient coagulant, boron -containing poly-silicate zinc (PSZB).The effect of the SiO2 concentration, Zn/Si molar ratio, B/Si molar ratio, activation time on flocculation properties were examined in detail. And the optimal preparation conditions were determined. At the same time, the industrial wastewater and life wastewater were treated for the properties test. The experimental results showed that the flocculant had good stability and good effect. It is a kind of good performance of flocculants.