The temperatures inside the gas turbine reach up to 1000°C, alloys used for gas turbine components must be oxidation, and corrosion resistant, and stable in structure under high temperature circumstances. A Co-based alloy was cladded on the 1Cr18Ni9Ti stainless steel surface using a high power carbon dioxide laser. The microstructure evolution and hot corrosion properties of samples in 75%Na2SO4+25%NaCl saline were investigated. The results show that the microstructures of the cladded layer is fine, and the hot corrosion resistance of the cladded layer was significantly improved because of the formation of a protective oxide film of CoO and CoO•Cr2O3. Under high temperature corrosive atmosphere, the high content of Co promoted the formation of the protective oxide film. The refinement of dendritic structures and the formation of Co-based alloy oxides lower the penetration rate of the sulphur ions that induce the intergranular corrosion.