In the work environment, the structure of aircraft’s hydraulic pipes and the fluid inside constitute a typical fluid-structure interaction (FSI) system, in which there are transfers of momentum and forces between the pipes and fluid. Excitation caused by high frequency pulsation of flow and pressure may lead to fatigue damage of the structure. In order to help the designers estimate the dynamic response of the aircraft’s hydraulic pipes, the FSI of aircraft’s hydraulic pipes is investigated in this paper. Using ANSYS CFX and ANSYS Mechanical as the tools, a finite element analysis was done to compute the stresses and strains of the fluid-filled pipes caused by high-pressure pulsation. Furthermore, the fatigue analysis was done to evaluate the safety of the structure.