Some kinds of solvents were utilized to investigate the influences of the compatibility between the polymers and their solvent on formation of honeycomb patterns. Polyphenylene Oxide (PPO), Poly (D, L-lactic-co-glycolic acid) (PLGA) and Poly (L-lactic-co-glycolic acid) (PLLGA) were dissolved in different solvents to form porous films. It was found that the good compatibility between the polymers and their solvents was beneficial to the formation of regular structures. Moreover, several solvents were fixed to form a serial of mixed-solvents which had different compatibility with the polymer, such as C2HCl3-CH2Cl2 mixed-solvent. These mixed-solvents were used to investigate in detail how the change of the compatibility between the polymer and its solvent influence the morphography of the polymer film. The result showed that, excluding the affection of the solvents’ evaporation rate, the pattern became more regular along with the improvement of the compatibility between the polymer and its solvent.