Paper Title:
2-(2'- Chloro Phenyl)- 5- (2'-Hydroxyl Phenyl)-1,3,4-Oxadiazole as a Florescent Probe for DNA Determination
  Abstract

In recent years, fluorescence spectrometry was widely used in quantitative determination of DNA. In this paper, a convenient synthesis of a new fluorescent 2-(2'- Chloro phenyl)- 5- (2'- hydroxyl phenyl)-1,3,4-oxadiazole (HOXD) was realized. Experimental data showed that fluorescence of HOXD could be quenched by DNA and the decreased fluorescence intensity of HOXD resulting from fluorescence quenching is proportional to DNA concentrations suggesting that HOXD could be used as a new fluorescent probe for quantitative determination of DNA. Optimal experimental conditions for DNA analysis were also studied in the paper.

  Info
Periodical
Advanced Materials Research (Volumes 301-303)
Chapter
Chapter 1: Material Science and Technology
Edited by
Riza Esa and Yanwen Wu
Pages
361-365
DOI
10.4028/www.scientific.net/AMR.301-303.361
Citation
M. Ding, Y. J. Lei, O. Y. Jie, "2-(2'- Chloro Phenyl)- 5- (2'-Hydroxyl Phenyl)-1,3,4-Oxadiazole as a Florescent Probe for DNA Determination", Advanced Materials Research, Vols. 301-303, pp. 361-365, 2011
Online since
July 2011
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Price
$32.00
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