Paper Title:
SiO2 Beads with Quantum Dots: Synthesis and Bioapplication
  Abstract

Aqueous CdTe and organic CdSe/ZnS quantum dots (QDs) were encapsulated into SiO2 beads using various controlled sol-gel processes. Ligand exchange is a key to adjust the QD number in each bead and get a high photoluminescence (PL). Namely, partial ligand exchange from thioglycolic acid to 3-mercaptopropyotrimethoxysilane (MPS) on the CdTe QDs enables retention of the initial PL efficiency of the QDs in water, while the simultaneous addition of a poor solvent (ethanol) resulted in regulated assembly of the QDs through condensation of hydrolyzed MPS. SiO2 beads thus prepared had, for example, a diameter of 17 nm and contained 3 QDs each. The PL efficiency of these beads was 30%, while the initial PL efficiency was 38% in a colloidal solution. In addition, a method including surface silanization, phase transfer and self-assembly, and SiO2 shell growth has been developed to incorporate multiple hydrophobic CdSe/ZnS QDs into SiO2 beads where they are well suited for bio-application due to their high brightness, less-cytotoxic, and non-blinking nature. To investigate the potential use for labeling in bio-applications, SiO2 beads with multiple QDs were conjugated with IgG using streptavidin-maleimide as linkers. This preparation method is an important step towards fabricating intensely emitting biocompatible SiO2 beads impregnated with semiconductor QDs.

  Info
Periodical
Advanced Materials Research (Volumes 306-307)
Chapter
Chapter 1: Biomaterials and Tissues
Edited by
Shiquan Liu and Min Zuo
Pages
16-19
DOI
10.4028/www.scientific.net/AMR.306-307.16
Citation
P. Yang, N. Murase, A. Y. Zhang, Y. Q. Cao, Y. N. Zhu, R. X. Shi, "SiO2 Beads with Quantum Dots: Synthesis and Bioapplication", Advanced Materials Research, Vols. 306-307, pp. 16-19, 2011
Online since
August 2011
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Price
$32.00
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