The MQ silicone resin was synthesized by using chlorotrimethylsilane and tetraethyl orthosilicate and its structure was analyzed by means of Fourier transform infrared spectroscopy, 29Si-nuclear magnetic resonance and gel permeation chromatography. The silicone based pressure sensitive adhesive was obtained by condensation polymerization between the MQ resin and methyl silicone rubber terminated with hydroxyl group. The structure of the adhesive was characterized by FTIR, and its thermal properties were investigated via thermogravimetic analysis. The results show that the MQ resin successfully had a condensation polymerization reaction with the silicone rubber. The pressure sensitive adhesive had excellent tack, peel strength and high temperature resistance properties.