Paper Title:
Preparation of a Thermo-Sensitive Poly(N-Acryloyl Alanine Methyl Ester) for Controlled Drug Release
  Abstract

A novel thermo-sensitive poly(N-acryloyl alanine methyl ester) (PAAME) was synthesized by radical polymerization. The structures of the corresponding monomer and polymer have been confirmed by 1H NMR and FTIR measurements. The thermo-sensitivity of PAAME was investigated by measuring their lower critical solution temperatures (LCST) in pure water and at different pH solution. The results indicated that PAAME exhibited a reversible thermo-sensibility in its aqueous solutions at 17.7 °C. The drug release study showed that 72% caffeine was released from hydrogel at 37 °C after 6 hours, while more than 94% caffeine was gradually diffused into the medium at 18 °C.

  Info
Periodical
Advanced Materials Research (Volumes 306-307)
Chapter
Chapter 6: Polymer Materials
Edited by
Shiquan Liu and Min Zuo
Pages
675-678
DOI
10.4028/www.scientific.net/AMR.306-307.675
Citation
K. L. Deng, H. B. Zhong, Y.’e Shi, J. Zuo, C. Y. Jiang, N. Li, X. J. Ji, P. F. Zhang, X. B. Ren, "Preparation of a Thermo-Sensitive Poly(N-Acryloyl Alanine Methyl Ester) for Controlled Drug Release", Advanced Materials Research, Vols. 306-307, pp. 675-678, 2011
Online since
August 2011
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Price
$32.00
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