Based on the time history analysis method, some curve long-span rigid frame bridge with super high pier in Sichuan was taken as the studying case, and a studying of natural vibration characteristics and seismic response. Comparative study was emphasis carried on seismic performance between the partial curve bridge and the straight. In addition, the exhaustive research to about between crosswise relation to the structure overall rigidity contribution and to the structure and the seismic performance influence is conducted. The conclusion of the study shows that the seismic performance of the straight long-span rigid frame bridge with super high pier is surpassing the curve bridge. The curve linear has little influence to the base frequency of this kind of structure, and The rigidity is mainly effected by the bridge pier. If additionally builds the crosswise relation between the structure, the dynamic characteristic of the structure will be improved greatly. The height of this type bridge has great influence on the dynamical stability, the height is lower and the dynamical stability is better, which is more advantageous to the structure seismic behavior.