In order to ensure the truth and feasibility of constraints during the optimization of suspension parameters, a method, combining gradient optimization with ADAMS, is put forward to optimize the suspension parameters of the truck, which can improve its running comfort and friendliness. Based on the evaluating indicators of ride comfort and road-friendliness, the impacts of suspension parameters on ride comfort and vehicle damage on the road were researched. According to multi-body dynamics theory, a virtual prototype model of the truck is built by ADAMS. The effect of traveling speed, suspension spring stiffness and shock absorber damping on vehicle ride comfort and road friendliness was analyzed. Then the suspension parameters, in favor of ride comfort and road friendliness, were obtained. It is helpful to design the suspension of truck.