Multidisciplinary design and simulation is a very effective process to balance the different discipline design requirements and gain the optimal design result. The paper proposes a master model approach in order to maintain the model associativity and consistency in multidisciplinary design and simulation for compressor blisk. The research presents a master model-centered model structure, which is composed of master model, context model and application model. In the proposed master model-based multidisciplinary design and simulation process, master model is the kernel model and shared by each discipline. In addition, there is an associative relationship among these models. Then, the paper studies the modeling method for the master model of blisk and the model mapping and associativity maintaining method for multidisciplinary design and simulation. A series of computation results demonstrate the performance of the proposed approach.